Out of over a dozen Ruger New Model single-action or double-action (RedHawk) revolvers ranging in age and fixed or adjustable sights, almost all of them (with only two or three exceptions) have over- or under-clocked barrels. I got to where I can tell just by looking over the gun, then confirming shooting from a solid rest. The adjustable sight models can be fixed by adjusting windage but all my Vaqueros would all shoot 2-4" left of point of aim at fifteen to twenty yards. To correct, I find loads (bullet weight and velocity) to matches elevation since I didn't want to fully commit to filing down my front sights. To correct windage I bent the front sight since I don't have a cylinder frame vice and barrel vice, and I don't have a local gunsmith to assist. I'm happy to get the Vaqueros to fire to point of aim at this short distance by bending the sight although most attest to breaking their sights. It is possible to achieve very good accuracy with a Vaquero, but I think two things are necessary: (1) try to settle on your favorite load (e.g., a fast-moving 158gr jacketed or lead bullet) that's precise (smallest groups) or does what you want (target or hunting), and (2) send it to a competent gunsmith to properly clock the barrel or replace the front fixed sight blade with a windage-adjustable model… if you do that, get a couple different height blades fitted to regulate it for different bullet weights,… and to further improve accuracy, get it fitted oversized base pin, and action job, and maybe darken in the rear-facing recess of the rear sight groove for improved sight alignment. Add some custom grips to better fit your hand to the gun and improve trigger finger positioning and then you'll end with with an accurate, fixed-sight beauty of a gun you'll likely never sell. It'll be your favorite forever. I own (or had) up to nine Vaqueros and these are the things I've learned about them. IMO, they're not worth keeping if they don't shoot to point of aim, but they're awesome after you regulate the sights.
Edited for typos