Most won't, but to be safe, like martyj said, cleaners WITHOUT Chlorinated anything would be wise.
Hoppe's 9 and CLP Breakfree are safe for polymer framed guns. A number of others are too....just don't use Brake or Carb Cleaner or other heavy automotive degreasers on any plastic/polymer parts, at the very least it can remove any paint on the guns (Fire/Safety markings mainly) and if they don't deteriorate the frame, they can atleast discolor it.
Josh