Used some Speer 250 swaged lead SWC's over 8.0 Grns of Unique. And a few of their 230 RN with that same powder charge.
The 250's burned cleaner and were far more accurate.
No leading to speak of from either.
Unique don't much care what primer you use, but I prefer the Winchester WLP's. Mostly because that's what I've used for the past few years, and have never had a problem from them.
If you're a hot rodder and like to run that type of bullet faster than what is considered normal for the 45LC, you might give some thought to lubing them with Alox before hand.
Hope this helps.
DGW