Everybody has different ideas on what THEY prefer for home self defense. (HSD) Joe likes his ideas and they are what makes him comfortable. Others prefer something different. Thank goodness we have so many choices. (Thanks Second Amendment.)
But real life scenarios are filled with variables. As noted,, a 260 lb thug just out of prison, vs a 110 lb junkie are two different types of targets. But often,, drugs are involved in many of these criminals.
Back before WWI, we had the .38 Spl for our soldiers. The Army discovered that the Filipino fighters would chew on CoCo leaves,, ( cocaine,) for battle. They would absorb 6 rounds of .38 Spl, and keep on fighting AND KILLING soldiers before dying. And often, only after more shots were used and often with other calibers. This is WHY the Army contracted for a better self defense, hand-to-hand distance firearm.
Along came the 1911 in .45 acp.
Drugged up thugs nowadays are no different. All too often,,, unless inflicted with a very lethal mobility stopping or limiting type of injury, the thugs can still do a lot of damage or kill others before going down.
Can small calibers in smaller guns kill? Absolutely. But the variables invite a much lower probability. Besides the potential for a drug induced attack, you have stress, accuracy, (which includes bullet placement,) bullet types, among the top reasons to consider something a bit larger in caliber.
I know that we have several Veterans here. And I'm sure many of them have either been shot, or saw people shot, or have shot the enemy. And I'd also bet a few of the folks here have also experienced the same thing.
I know,, I'm in within the category of these things in a couple of places.
So, when I teach our handgun clinics to the ladies,, who are mostly there for HSD, I teach the following;
Be willing to kill someone in SD before getting a firearm.
Be willing & dedicated to proper training & regular practice with a firearm if you get one.
Get a firearm that fits YOU and a type you can comfortable operate.
Get the best you can afford, to assure you can bet your life on it.
Get the best SD ammo available for carry.
And lastly, get a caliber as big as you can handle, that has a much better chance of a one shot stopping power on a big drugged up thug.
One shot may be all you get.