Mzimmer: I know you already know this stuff but change one thing at a time.
If I was reloading I'd start with the load that gave you the best groups to date and then use a couple of different bullets with it. Your rifle may finicky regarding the bullet, either manufacturer or weight.
I'm going to start with my own #1 in the 204 Ruger in a stainless/laminate "V" that I just bought, as soon as it cools off a little.
Even though I already have 2 other #1s in 204 I won't even start with the loads from those rifles, an "AB" and a "B".
What I usually do is look through the manuals and find the accuracy load from Nosler, Hornady, Speer, etc. I'll load 5 different loads that utilize 5 different powders and see what this rifle likes. One will be better than the others.
I then use the powder that worked and load 5 loads with 2 on either side of the base load and see if velocity makes a sinificant difference. If it does then I refine that till it quits getting better.
Then I'll use a variatey of bullets and find the bullet weight the rifle likes.
Then I play with the primers that are available and see which it likes.
Then predicated just how much I want/need to shrink groups I mess with seating depths.
When I'm done with all that I install the foreaen and just barely tighten it. Then I increase the screw tension till the groups go to Hell.
When I'm all done I know what forearm tension the rifle likes along with the powder, bullets, primer, seating depth and velocity that the rifle likes best.
A classic example of the same rifles different loads thing is Cousin Waynes and my 17 Mach IVs. We built identical rifles starting with the use of a #3 action. Both have 22" long Shilen tubes in the same profile and both were chambered, threaded and the rest of the work done by Shilen. For rifles that for intent and purposes it's amazing when you look at the loads. Mine likes a 25 grain Remington factory bullet, with IMR4227 and a CCIBR4 primers at 3200 fps. Whnen we tried that load in Waynes rifle it shot patterns. I thought Wayne was going to cry, he was so frustrated. I sent him away and started from scratch. It turns out his rifle prefers a 20 grain Hornady V-Max bullet, a Remington 7 1/2 primers and H1000 driving the bullet to 3600 fps.
We just have to be careful to not mix ammo. Mine are in blue boxes and his are in green.
Ruger #1s can be finickt. ;-)
the best
Ross