It's actually better to have a case that is full to the base of the bullet. I was just recently re-reading some info on how light charges can cause a much higher pressure spike,, due to powder position & the way it ignites.
Many, many years ago,, I spent a lot of time studying what Rick Jamison would write in his "Reloading" column for Shooting times. One thing that always stood out was how the most uniform & consistent loads were from using a powder that would allow a safe charge,, to where it just touched the base or was slightly compressed.
A very light charge,, where there is a bit of "air space" inside the case,, when loaded in the gun,, the powder lays in the bottom of the case. The primer flashes across the powder. That causes erratic ignition and can create a larger pressure spike. In the case of what you are showing above,, I'd go with the 4198 powder instead of the Unique.
And I use a lot of Unique in a lot of handgun loads. But in general,, it is used in an amount to where the primer can ignite the powder while the powder is still against the base of the case internally.