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Never loaded 45 Colt but put a lot of 250 gr cast downrange in a S&W 29. Standard load for me was 9.0 gr Unique which is midway between start and max loads listed in the old Lyman 45th Edition. A quick check show that load is midway also n the 45 Colt with 255 gr cast. Note this is with lead not jacketed bullets. More of an issue is what powders you can find available.
 
".45 Colt and .44 Remington Magnum do not use nearly the same powder"

They do in my room. I load 45 Colt @ Ruger +P levels with H110, same as 44 mag. Not advisable for lesser built guns, but the Bisley handles them with authority.
 
Another 231 fan here. If you're wanting something in between 231 and 296 (H110) I'd suggest looking at WSF, which is very similar to unique in its speed and applications.
 
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