The .17 HMR (Hornady Magnum Rimfire) is based on the .22 mag case. The .17 Mach 2 is based on the Long Rifle case. I have two guns in the HMR and it is a scorcher for gophers but expensive. I am now paying $12.99 for a box of 50. The Mach 2 is cheaper but more than .22 LR.
I did once try to shoot a Mach 2 in an HMR chamber and found out that the case heads are different sizes. The Mach 2 would not fire. These calibers are available in just about any gun that was already being sold as a .22 so there are many choices out there for long guns and hand guns.
At one time and maybe still so, all .17 HMR cartridges were being manufactured by CCI regardless of what label was on the box. I don't know if that is the case for the Mach 2.
I did once try to shoot a Mach 2 in an HMR chamber and found out that the case heads are different sizes. The Mach 2 would not fire. These calibers are available in just about any gun that was already being sold as a .22 so there are many choices out there for long guns and hand guns.
At one time and maybe still so, all .17 HMR cartridges were being manufactured by CCI regardless of what label was on the box. I don't know if that is the case for the Mach 2.