Wow , back after 6yrs !
But anyway , with magnums my default starting point is what ever is about 95% load density with particular bullet. It has always given at least decent accuracy. Work up to compressed to either fine tune accuracy , or if more vel is desired. While I typically use the WLP, standard primers for magnum-ish loads.
While not initially listed by OP , in .45LC in the neighborhood of 20.0 with a 250-255 cast will give aprox 1000fps with aprox 20K pressure.
Ironically , if loading outside usual parmeters in a low pressure application (ie .38spl +P , etc) a magnum primer will help with consistancy.
FWIW , since Hogdons took over IMR , the 4227 has been identical for either IMR or H on the label. Supposedly they will currently only market it under IMR label.