So, 45 Colt Bisley. Shooting it sucks with any load. I can't imagine it with something with 110 0r 296 and a 300 grain bullet. The trigger guard really whacks the middle finger of the shooting hand. No joy with a glove. The web gurus suggest only a Bisley frame for the hot stuff. Baloney! I can't find a aftermarket grip the fill in the space behind the trigger guard like Pachs and Herritts do for the Blackhawk. My 45 Blackhawk works with those grips. Anyone know of a custom grip maker or any type of adapter that will work. The Tyler adapter I have is not a perfect fit and is currently held on with a rubber bank. I haven't tried it yet but have high hopes. I might even have to switch it to a Blackhawk grip frame because good grips ave available. I'm talking 260 bullet and 8 grains of Unique and pain.