Welcome to the Forum!
I shoot mostly cast in my handguns. First off,, have you slugged the bore? You need to make sure you match the bullet to the bore diameter. (Usually .001 bigger bullet than the bore diameter.) My (2) .480 Rugers shoot VERY accurately with a properly cast & sized cast bullet.
You mention an abrupt 45 degree transition. If I understand your comment,, are you saying the transition point from the cylinder to the barrel?
That would be the forcing cone,, and none of the Rugers I've ever heard of,, outside factory testing exceeded 11 degrees.
If you are discussing the shoulder from the case to the throats within the cylinder,, then I have heard of some people thinking this is causing shaving or accuracy issues.
Some of the earlier cylinders were known to have been cut "tight" causing extraction issues or such.
A little more info might help us offer assistance.
But as hittman has mentioned,, we have a member here,, "Fermin Garza" known as "2 dogs" here who does excellent cylinder work. His number; 361-960-3697. Call him. He's a great guy!