I had a couple No.1 rebarreled in revolver cartridges (445 Super Magnum and 500 S&W). The biggest problem I had was sight regulation, but that was before Ruger introduced the No.1 in revolver cartridges like the 475 Linebaugh, 44 Mag, and later the 460 S&W. AA1680 is a great powder that meters well and burns cleanly. If you have problems with sight regulation, try the Barnes bullets that are long, light, and tough. Partitioned bullets will also ensure it holds together for hunting. Also, look in your load books for data for the rifle section for your cartridge since it should list bullets that are designed to give good terminal ballistics at higher velocities. A good example, if memory serves me, is the 265gr for the 44Mag.