I have one.
A few years ago, I was kind of keeping my eye open for a Bisley New Vaquero, thinking one of those in .357 would be fun to have. I came across an "old" large-frame model in excellent shape for the right price, so I grabbed it right away.
What can I say? It's heavy. I like the smooth contours--nothing snaggy on it. All surfaces are polished to a mirror shine. The wood grips fit well, but not perfectly. There's a big ol' paragraph stamped on the left side of the barrel, and it's stamped deep. There's so much meat in the cylinder, I never fear to shoot high-pressure loads.
I love how it points.
I hate how heavy the trigger is. This was also my biggest complaint about a plow-handle stainless Vaquero I once owned. My blued .45 convertible Blackhawk has a better trigger, and my anniversary model .357 flat top puts it to shame. I'm thinking about sending it to a good smith for some tuning.
I just received a simple shuck holster from Doc Barranti, intending it for this one. The fit is really nice, and it carries pretty well (except that it's heavy).
Oh, maybe most important of all... the angle of the Bisley grip, combined with the 4 5/8" barrel, makes this my best gun for pounding in nails--you know, to hang up wanted signs and stuff.
(Only kidding on that last one.)