For my weekly trips to the range, I take at least 2 guns. I always start off shooting at least 100 rounds of .22LR, even if the gun I am primarily shooting on the trip is one of my .45 Colts or CCW .380 ACPs. Many trips are strictly .22LR days, putting 300-500 rounds through one, or more, of my Ruger semi-autos.
As you can see, I have a little variety of choice in what I can shoot, an SR22 and 4 Mark IIs with different set-ups. The SR22 can be used for most of the same type of drills and training as appropriate for my CCW guns. The Mark IIs provide options for different types of challenges.
The Target model has a Burris FastFire 3 red dot so I can push it out to some longer ranges. The Competition Target has been fitted with Standard grips (since I'm not a bullseye shooter, I found that I didn't really like the thumb rest) and Williams Firesights and is my most accurate open sight handgun. The 22/45 also has Williams Firesights and is my favorite shooter, capable of putting 100 rounds into a 6 inch circle at 7 yards as fast as I can pull the trigger. (I do prefer the shape of the Mark II 22/45 grip to the grip on my son's Mark IV 22/45.) The Standard lets me play with the base model, and try some point/hip shooting, since I find the grip angle to be a more natural pointer, kind of like a single-action.
That, pretty much, covers all of the shooting I want to do on a regular basis.
If I need a real change of pace, I can pull out my Single-Six or 10/22.