In general terms I'll use Blue on fasteners between SAE number 6 up to number 10 or their metric equals on things that you know will need to be taken apart. If it's something I don't expect to ever take apart again AND it can withstand about 300 degrees of heat I'll go to Red.
Only use the low strength stuff on tiny screws.
You don't need to drown the hardware....just a drop or so usually, and if it's critical clean the threads ( both ) with a no residue solvent and dry them well.
If you are taking apart something that has thread locker on it heat is your friend, most go soft at 250 to 300 degrees. On something heat sensitive a soldering iron on the screw head is often enough heat to do it