A few years ago I discovered the fastest way to reload a .22 DA revolver was to carry the ammo in a nifty little Uncle Mike's Velcro-secured belt pouch, and grab two or three rounds at a time by the rim ends, and simply stuff them in. With some practice, your fingers can become amazingly adept at finding and aquiring two or three rounds in this fashion, and sometimes you even grab them just right so you can put them into the chambers two at a time. It only takes a few seconds to reload this way, and is much less bother than screwing around with a speedloader.
As a practical matter, however, I think "speedloading" a .22 revolver is pretty much a moot issue. You shouldn't be carrying a .22 revolver for self defense in the first place (carry something more powerful), and if you are, you most likely won't have the need or get the chance to speed-reload it. By the time you've packed up a .22 revolver and a couple of speedloaders (and some means to keep the latter clean and lint/dust-free), you've easily got as much bulk involved as simply going to a much better weapon in the first place.
I love my .22 DA revolvers and shoot them often, but I have no illusions about what they are and aren't.