dovetail size 22/45 and SR22 pistols

I've been giving some thought to adding an optic to my SR22 to see just how accurate it is or isn't. I have a 22/45 dovetail mount but don't know if the slide profile or dovetail slots are anywhere near compatible.
Has anyone tried this?

I gave my SR 22 to my nephew's bride so I can't check this, but isn't the rear sight mounted on the slide? If it is, I'll be surprised if the added weight of a red dot sight doesn't cause function problems.

Good point and I hadn't thought about that issue. Doesn't seem to affect centerfire pistols but 22's could easily be affected.