I have used the Ruger Silent SR, SilencerCo Spectre and Sparrow, and the Innovative Arms Slingshot (I am a suppressor dealer so I have a number of different types to demonstrate). With subsonic ammo, in a bolt or single shot it is almost Hollywood quiet, but remember they are suppressors not silencers (although both terms are commonly used to describe them).
Be aware that on some semi auto .22 rifles, the 10/22 included, the subsonic ammo with the suppressor may not have enough pressure to actuate the bolt. With standard or high velocity ammo, the semi autos will work better but the sound will be a little louder and you may hear the supersonic crack.
Accuracy should not be affected by the addition of a suppressor and in fact, many who use a suppressor on a larger caliber gun have found better accuracy (possibly because of the additional weight creates different barrel harmonics.
With my Ruger American Rimfire I can sit on my back deck and take care of the varmints and the neighbors (150 ft away) don't suspect a thing. In fact, with my Ruger American Ranch or my AR-15 in 300 Blackout (using a Rugged (the brand name) Surge 762 suppressor) I can shoot it and they won't hear it either.
A .45 ACP with the correct suppressor can be fired without hearing protection if using standard 230 gr ball ammo (since it is subsonic).
Do not use Hollywood sound effects to give you a realistic rendition of how a suppressor sounds. If you do, you will be disappointed. That said, suppressors DO make quite a difference, especially in .22's and yes they can be quieter than a pellet gun