My process goes like this. I get the gun dimension-ally correct. Ie. I set the cylinder throats to .452 (Both of my Vaqueros were tight, my original Vaquero was ~.449). I set the forcing cone to proper angle. Shoot it. If there is leading, I take care of that next (fire-lapping in one Vaquero). Now I find a load that groups well for the bullet this gun will be using. In this case a 250g RNFP. I don't care where it groups, as long as the group is tight enough. Now the gun goes to the gunsmith for a tune-up. Then later we meet out at the range. He has a barrel-vise on his truck. He turns the barrel, I shoot at a 25Y target. Usually takes a few times to get it 'right'. Now it is vertically corrected. Then, over a few sessions, I carefully file down the front sight to bring up to POA. Done. Ready for a long life of usage. Side note, this gunsmith would normally shoot it himself, but he and I see the sights slightly differently we found.
This is why, most people prefer adjustable sights as it isn't as much of a hassle to get them to shoot straight. I just really dislike having to use Kentucky windage on any revolver. Anyway, Ruger may be able to help. Give them the yards and the offset in the box with the gun and they may be able to realign the barrel slightly for you. Bending the front sight is dicey as you might break it off. Filing the rear sight works but opens up the sight picture which can make it harder to shoot tight groups (if you care about that).