As noted,, one consideration is to ask yourself what you'll use it for.
I own a Freedom Arms in 454 Casull. I also own 3 Rugers in 480. It wasn't planned that way,, it just sorta happened. I got my first 480 because I helped a guy get it,, and told him I had the "right of first refusal" for doing so. Yep,, after 2 years,, he "wanted something else," and I got it for a VERY good price.
I didn't "need" a caliber that big or such,, but I was surprised at how accurate it was,, along with how pleasant it was to shoot.
I had shot a FA in 454,, and the felt recoil was sharp & noticeable.
But,, again,, a deal came along and it was too good to pass on,, so I became the owner of a 454. Then,, a second 480 was offered with the longer barrel,, and again,, the price was one to not pass up. Soon after,, the Ruger Bisley in 480 was introduced,, and I had to have one.
So,, I now have a pair of single action's one in 454 & one in 480.
I shoot both,, and load for both,, and both enjoy reasonable availability of components.
For pure recoil comfort,, the 480 gets the nod IN MY HANDS!!!!!! Follow that with the ability for it to use a 400 grn slug,, easily,, makes it a fun big bore.
The 454,, while it has a sharper felt recoil,, it has the versatility of being able to use 45 Colt brass,, and ammo.
So,, as you can see,, both have their pro's & cons. A lot depends upon what your use for it is.