Yeh, I think the trigger on the 22 Magnum is going to be a little too beefy for her wrist. I'd lean more towards the 38 with a lighter load. The reality is, God forbid, but should she ever need to use it, I'm sure she probably wouldn't even be phased by any potential recoil concerns. But, regardless,... she needs to be able to pull the trigger. The 22 Mag is a great revolver and a good round in the home defense ammo, but I just pulled the trigger on one myself a few days ago at a LGS, and it was really heavy. Very stout!!!
Best of luck. Keep us posted on what you/she decides.
Stay safe out there!!!