Way back when Titegroup came out, it was touted as being less position-sensitive and thus better (more accurate) in guns like .38 Special and .45 LC with loads where the cartridge was not completely full of powder. I did a little experimenting with loads of that sort, including .45 LC and .45-70. My procedure, with my NEF Handi-Rifle, was to load the round, point the rifle either up, down, or level, slap it once or twice to joggle the powder, then bring the rifle to level and fire it over the chronograph. The idea was as much as possible to position the powder against the primer or against the base of the bullet, or sort-of-level in the case. My notes are not convenient to hand, but there were noticeable and fairly consistent differences with powder position. My memory may be faulty, but it seems the bullet was faster with the powder near the primer, slower with the powder "level," and slower yet with the powder near the bullet. This effect would no doubt not appear with case capacity loads. I wonder whether the advent of Trail Boss, a much bulkier powder, might reduce the effect in Cowboy loads.