First rule of a gunfight; Have a gun.
Without the heated debates about calibers, penetration etc for a SD gun, the first thing about selecting a firearm for yourself is one you can shoot, COMFORTABLY, and having it fit YOU!
I teach a lot of ladies to shoot.
I find you have done right by allowing her to enjoy a 22, & where her dislikes of a 9mm have made you focus on a caliber she can shoot.
I will offer this. If at all possible, let her shoot a LCR in 22 mag before you purchase one. It will be different than the 22/45 she has tried. She needs to be the one to select her gun of choice. Again, it falls back to rule number one.