Bob,,,, certain calibers & brass work better with different powders than others. The 327 is similar to the 357 Maxi in how it's designed. They just kept stretching the chambers & lengthening the cases to give us a more powerful caliber.
Back before the 357 Maxi a lot of folks would shoot mild 38 spls in their 357's, using light target loads. A mild 38 spl case, loaded with around 3.5 grns of Bullseye, with a full wadcutter would work great, because it mostly filled the case capacity. But if still had a space gap inside. If you chose to use 357 brass & duplicate the load, the internal space was increased. While I never heard of anybody doing this with a 357 Maxi,,, it is a possibility. But back in the 70's while talking to serious competition shooters,,, I discovered that to get safe consistent loads was to use a "filler" on top of my powder when loading 38 spl target loads. And I was told to definitely use a filler if I used 357 mag cases. It was to reduce the internal space in the case.
Why?
Because a light charge of a fast burning powder like Bullseye would be spread along the sidewall of the case when being fired, & wouldn't be on top of the primer. The primer flash would ignite all across the powder, instead of just in one spot under it. It could create unsafe pressures due to the different burn rate of the internal combustion. (Think of it, you load the cases with powder while they are standing, mouth up. But once loaded, you are laying them sideways.)
So I used a polyester fiber fill material, made little wads of it, seated them over the powder while loading, and then seated bullets. I'd get very consistent reloads like that & never had any issues.
Now, you can use Bullseye in 32 Shorts, & Longs with those wadcutters, and shoot them in your 327 Mag handgun doing the same things. But to use 327 cases, and a light load of Bullseye,,, you could possibly be courting a potentially dangerous pressure spike.